Howtoforge posted a tutorial about setting up Mepis 11 as Windows desktop replacement

This tutorial shows how you can set up a Mepis 11 desktop that is a full-fledged replacement for a Windows desktop, i.e. that has all the software that people need to do the things they do on their Windows desktops. The advantages are clear: you get a secure system without DRM restrictions that works even on old hardware, and the best thing is: all software comes free of charge. Mepis is a Linux distribution based on Debian Stable.

  The Perfect Desktop - Mepis 11